B cell epitope specificity in ANCA-associated vasculitis: does it matter?
نویسندگان
چکیده
منابع مشابه
Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis.
Anti-neutrophil cytoplasmic antibody-associated (ANCA-associated) small vessel necrotizing vasculitis is caused by immune-mediated inflammation of the vessel wall and is diagnosed in some cases by the presence of myeloperoxidase-specific antibodies (MPO-ANCA). This multicenter study sought to determine whether differences in ANCA epitope specificity explain why, in some cases, conventional sero...
متن کاملUpdates in ANCA-associated vasculitis.
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Renal-limited ANCA-associated vasculitides can be considered the fourth entity. Despite their rarity and still unknow...
متن کاملTreatment of ANCA – Associated Vasculitis
ANCA – associated vasculitis (AAV) encompass Wegener granulomatosus (WG), Churg Strauss syndrome (CSS) and Microscopic Polyangiitis (MPA). Granuloma formation characterizes both WG and CSS, while necrotising inflammation of middle to small arteries, pauci-immune glomerulonephritis and production of ANCA typify all three of them. Common clinical and laboratory features point towards common patho...
متن کاملEpidemiology of ANCA associated vasculitis
ANCA associated vasculitis (AAV) comprises three syndromes with systemic vasculitis (Wegener’s granulomatosis (WG), Churg Strauss syndrome (CSS) and microscopic polyangiitis (MPA)), which all involve small and medium sized vessels and are associated with antibodies against cytoplasmatic antibodies in neutrophils (ANCA). Polyarteritis nodosa (PAN) is included in this review as it also affects me...
متن کاملANCA-associated small-vessel vasculitis.
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is the most common primary systemic small-vessel vasculitis to occur in adults. Although the etiology is not always known, the incidence of vasculitis is increasing, and the diagnosis and management of patients may be challenging because of its relative infrequency, changing nomenclature, and variability of clinical expression. ...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 2004
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.2004.02572.x